I. You infect mice with mouse mammary tumor virus (a retrovirus). After a period of time most infec Show more I. You infect mice with mouse mammary tumor virus (a retrovirus). After a period of time most infected mice develop breast tumors whereas uninfected mice do not. You then isolate cell lines from over 50 independent tumors and you observe that all 50 lines have virus integrations in the same chromosomal location. Can one conclude that the virus integrates into cellular DNA at only one site? Explain. II. The ras oncogene is involved in a variety of human and animal cancers. DNA is isolated from a number of normal and cancerous tissues and the following experimental steps are performed: a) How do you explain the presence of sequences complementary to the oncogene in the DNA from healthy human and mouse samples? Why dont they have cancer? b) Why is the hybridizing band from sample 1 a different size than that from sample 5? c) For each cancer examined above based on the autoradiogram choose the most likely mechanism of transformation from four options below and explain your choice: Choose a mechanism for: Lane 2 human lymphoma cells (cancerous): Choose a mechanism for: Lane 3 human bladder carcinoma cells (cancerous): Choose a mechanism for: Lane 4 human sarcoma cells (cancerous): Choose a mechanism for: Lane 6 mouse myeloma cells (cancerous): Show less
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